Clinical Research Associate 2, Sponsor Dedicated, …, Centurion

Clinical Research Associate II (CRA II)

Sponsor Dedicated

Johannesburg Based

Job Overview

The CRA II performs site monitoring and management activities to ensure clinical studies are conducted in accordance with study protocols, applicable regulations, and sponsor requirements.

Key Responsibilities

Conduct site monitoring visits (selection, initiation, routine monitoring, and close-out) in line with GCP, ICH guidelines, and contracted scope

Drive and support subject recruitment strategies at site level to meet enrollment targets

Deliver protocol and study-related training and maintain effective communication with investigative sites

Assess site performance to ensure quality, data integrity, and regulatory compliance; escalate issues as needed

Track study progress including regulatory submissions, enrollment, CRF completion, and query resolution; support study start-up where required

Ensure essential documents are complete and filed appropriately in the TMF and maintained in the Investigator Site File (ISF)

Prepare monitoring reports, follow-up letters, and maintain accurate site documentation

Collaborate with cross-functional study teams to support project delivery

Support site-level recruitment planning and, where applicable, site financial management activities

Qualifications & Experience

Bachelor’s degree in life sciences or healthcare (or equivalent combination of education and experience)

Minimum 2 years of on-site monitoring experience

Mandatory Oncology therapeutic area experience

Strong knowledge of GCP, ICH guidelines, and clinical research regulations

Good therapeutic area and protocol understanding

Proficiency in Microsoft Office (Word, Excel, PowerPoint)

Strong communication, organizational, and problem-solving skills

Ability to manage time, priorities, and stakeholder relationships effectively

IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more at

IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for candidate fraud. All information and credentials submitted in your application must be truthful and complete. Any false statements, misrepresentations, or material omissions during the recruitment process will result in immediate disqualification of your application, or termination of employment if discovered later, in accordance with applicable law. We appreciate your honesty and professionalism.